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VDJServer: An Immune Repertoire Data Management and Analysis Portal

Novel insights on how vaccines induce long term protection against pathogen challenge will be discussed in this talk


Speaker Info:

Dr. Lindsay Cowell
Associate Professor
Department of Clinical Science, UT Southwestern Medical Center, Dallas, Texas


Speaker Bio:

Dr. Lindsay Cowell received a MS in Biomathematics with a minor in Mathematics in 1995 from North Carolina State University. In 2000, she received a PhD in Biomathematics with a minor in Immunology, also from North Carolina State University. She spent three years as a postdoctoral fellow in the Department of Immunology at Duke University Medical Center and then became an Assistant Professor in the Department of Biostatistics and Bioinformatics. She was also on the graduate faculty at Duke for the Computational Biology and Bioinformatics Graduate Program. In September 2010, she joined the Biomedical Informatics Division in the Department of Clinical Sciences at UT Southwestern.

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The theme for the Fall 2014 program of the Coast to Coast Seminar Series is “Deep Sequencing Antibody and T-cell Receptor Repertoires for the Study of Infectious and Autoimmune Disease, and Development of Vaccines and Therapeutics”. The sessions will examine an immediate and pressing “Big Data” problem faced by researchers examining the immune response to infectious and autoimmune diseases, and those developing vaccines and therapeutic antibodies.

The series is partly motivated by a specific middleware prototype that The IRMACS Centre is developing called iReceptor, supported by CANARIE. More importantly, the proposed series will be an important opportunity to help integrate the Canadian and greater international community that is grappling with this Big Data problem, and who will be participating in a series of “Workshops on Analysis, Storage and Sharing of Next-Generation Sequence Data from B-cell Receptor/Antibody and T-cell Receptor Repertoires” to be held May 29-June 1, 2015 in Vancouver.