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Case Study: Genomics, Bioinformatics & HPC - How Computational Analyses Are Transforming Infectious Disease Control
Fiona Brinkman, a Professor with the Department of Molecular Biology and Biochemistry, Simon Fraser University, uses an interdisciplinary approach to develop improved computational methods that (1) aid prioritization of the most promising infectious disease drug/vaccine/diagnostic targets, and (2) improve our understanding of the evolution of infectious disease to develop more sustainable approaches for infectious disease control.
This type of research generates large volumes of data in the form of DNA/RNA sequences, molecular structures, and molecular network changes - using significant amounts of space and computational power in the analysis.
In this talk, Brinkman will highlight selected research projects, outlining the top computational challenges her lab encounters, explaining how WestGrid facilities are used to help overcome those challenges, and highlight key outcomes achieved as a result.
One of Brinkman’s current projects is the InnateDB project, which involves collecting information about molecular interactions associated with the immune system, to facilitate more systems-based analyses of immune responses to infection. Shown here is a collection of molecular interactions associated with innate immunity, with those added in 2011 and 2012 highlighted in red.