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Productive Application of Repertoire Analysis in Vaccinology, Oncology, Bioengineering and Biomedicine
Jacob did his undergraduate studies in Molecular and Cell Biology at UC Berkeley, with an emphasis in Genetics, Genomics and Development. He performed research in two academic laboratories that specialized in quantitative biology. In Dr. Glenys Thomson's HLA Population Genetics laboratory, Jacob designed HLA allele drift simulators, and developed equivalency metrics across HLA typing protocols of various resolutions. In Dr. Sjolander's Berkeley Phylogenomics Group, Jacob published an automated webserver pipeline for phylogenomic functional analysis of proteins. In March 2008, Jacob was recruited to become Principal Scientist at Pfizer's Rinat research facility, where he developed novel computational immunology methods for characterizing and optimizing functions of the adaptive immune system. His published research emphasizes the sequence, structure and functional analysis of antibody repertoires for characterizing genetic variation in patient populations, optimizing phage display libraries based on profiles of natural selection, and engineering monoclonal antibody biologic medicines. Jacob joined as the Scientific Director of Distributed Bio in April 2012.
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The theme for the Fall 2014 program of the Coast to Coast Seminar Series is “Deep Sequencing Antibody and T-cell Receptor Repertoires for the Study of Infectious and Autoimmune Disease, and Development of Vaccines and Therapeutics”. The sessions will examine an immediate and pressing “Big Data” problem faced by researchers examining the immune response to infectious and autoimmune diseases, and those developing vaccines and therapeutic antibodies.
The series is partly motivated by a specific middleware prototype that The IRMACS Centre is developing called iReceptor, supported by CANARIE. More importantly, the proposed series will be an important opportunity to help integrate the Canadian and greater international community that is grappling with this Big Data problem, and who will be participating in a series of “Workshops on Analysis, Storage and Sharing of Next-Generation Sequence Data from B-cell Receptor/Antibody and T-cell Receptor Repertoires” to be held May 29-June 1, 2015 in Vancouver.
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For more information on other seminars and workshops offered through WestGrid, please visit our Training and Seminars page.